Relationship between glycaemic levels and arterial stiffness in non-diabetic adults
Med Clin (Barc). 2018 Jan 23;150(2):56-60.
doi: 10.1016/j.medcli.2017.06.072.
Epub 2017 Sep 18.
[Article in
English,
Spanish]
Affiliations
- 1 Centro de Investigación Sanitaria y Social, Universidad de Castilla-La Mancha, Cuenca, España.
- 2 Centro de Investigación Sanitaria y Social, Universidad de Castilla-La Mancha, Cuenca, España; Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile. Electronic address: Vicente.Martinez@uclm.es.
- 3 Instituto de Investigación Biomédica de Salamanca (IBSAL), Unidad de Investigación de Atención Primaria, Centro de Salud La Alamedilla, Servicio de Salud de Castilla León, Salamanca, España; Departamento de Enfermería y Fisioterapia, Universidad de Salamanca, Salamanca, España.
- 4 Instituto de Investigación Biomédica de Salamanca (IBSAL), Unidad de Investigación de Atención Primaria, Centro de Salud La Alamedilla, Servicio de Salud de Castilla León, Salamanca, España; Departamento de Medicina, Universidad de Salamanca, Salamanca, España.
- 5 Instituto de Investigación Biomédica de Salamanca (IBSAL), Unidad de Investigación de Atención Primaria, Centro de Salud La Alamedilla, Servicio de Salud de Castilla León, Salamanca, España; Departamento de Ciencias Biomédicas y Diagnósticas, Universidad de Salamanca, Salamanca, España.
Abstract
Objective:
To examine, in a non-diabetic population, whether the association between arterial stiffness and glycaemic levels depends on the test used as a glycaemic indicator, fasting plasma glucose (FPG) or glycated haemoglobin A1c (HbA1c).
Patient population and methods:
A cross-sectional analysis of a 220 non-diabetic subsample from the EVIDENT II study in which FPG, HbA1c and arterial stiffness-related parameters (pulse wave velocity, radial and central augmentation index, and central pulse pressure) were determined. Mean differences in arterial stiffness-related parameters by HbA1c and FPG tertiles were tested using analysis of covariance.
Results:
All means of arterial stiffness-related parameters increased by HbA1c tertiles, although mean differences were only statistically significant in pulse wave velocity (p ≤.001), even after controlling for potential confounders (HbA1c <5.30% = 6.88 m/s; HbA1c 5.30%-5.59% = 7.06 m/s; and HbA1c ≥5.60% = 8.16 m/s, p =.004). Conversely, mean differences in pulse wave velocity by FPG tertiles did not reach statistically significant differences after controlling for potential confounders (FPG 4.44 mmol/l = 7.18 m/s; FPG 4.44 mmol/l-4.87 mmol/l = 7.26 m/s; and FPG ≥4.88 mmol/l = 7.93 m/s, p =.066).
Conclusions:
Glucose levels in a non-diabetic population were associated with arterial stiffness but better when levels were determined using HbA1c.
Keywords:
Arterial stiffness; Fasting plasma glucose; Glucosa plasmática en ayunas; Glycated haemoglobin; HbA1c; Hemoglobina glicosilada; Pulse wave velocity; Rigidez arterial; Velocidad de la onda de pulso.
Copyright © 2017 Elsevier España, S.L.U. All rights reserved.
MeSH terms
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Adult
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Biomarkers / blood
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Blood Glucose / metabolism*
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Blood Pressure
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Cross-Sectional Studies
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Fasting
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Female
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Glucose Tolerance Test
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Glycated Hemoglobin / metabolism
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Humans
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Male
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Middle Aged
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Pulse Wave Analysis
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Vascular Stiffness / physiology*
Substances
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Biomarkers
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Blood Glucose
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Glycated Hemoglobin A
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hemoglobin A1c protein, human