An Update on Randomized Clinical Trials in Melanoma

Giorgos Karakousis; Charlotte Ariyan

doi:10.1016/j.soc.2017.05.002

An Update on Randomized Clinical Trials in Melanoma

Surg Oncol Clin N Am. 2017 Oct;26(4):559-586. doi: 10.1016/j.soc.2017.05.002.

Authors

Giorgos Karakousis¹, Charlotte Ariyan²

Affiliations

¹ Department of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce St # 4, Philadelphia, PA 19104, USA.
² Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: ariyanc@mskcc.org.

PMID: 28923220
DOI: 10.1016/j.soc.2017.05.002

Abstract

Despite many advances in the treatment of melanoma, it still continues to be a disease that affects many people. Fortunately, there have been a multitude of randomized trials that have refined the treatment of this prevalent disease. From 1975 to 2000, there were 154 prospective randomized trials on the treatment of local, regional, and metastatic melanoma. From 2001 to now, additional randomized trials have focused on the role of surgery, adjuvants to surgery, and treatment of metastatic disease. The results of the practice-changing trials are summarized in this review.

Keywords: Management; Melanoma; Randomized controlled trials.

Publication types

Review

MeSH terms

Humans
Melanoma / pathology
Melanoma / therapy*
Randomized Controlled Trials as Topic*
Skin Neoplasms / pathology
Skin Neoplasms / therapy*
Treatment Outcome