Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer

World J Surg Oncol. 2017 Sep 18;15(1):173. doi: 10.1186/s12957-017-1221-5.

Abstract

Background: Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer. However, it is unclear whether Foxp3 is correlated with lymphangiogenesis of cervical cancer.

Methods: In this experiment, expression of Foxp3 and VEGF-C was detected in 50 cervical cancer samples by immunohistochemistry. In addition, we evaluated the association between Foxp3 and VEGF-C expression and lymphangiogenesis of cervical cancer evaluated by lymphatic vessel density.

Results: These data demonstrate Foxp3 is positively correlated with VEGF-C expression. Furthermore, Foxp3 is associated with lymphangiogenesis of cervical cancer.

Conclusions: These results revealed Foxp3 play an important role in lymphangiogenesis of cervical cancer.

Trial registration: Gunagdong Medical University, PJ2013049.

Keywords: Cervical cancer; Foxp3; Lymphangiogenesis.

MeSH terms

  • Antibodies, Monoclonal, Murine-Derived / immunology
  • Female
  • Forkhead Transcription Factors / metabolism*
  • Humans
  • Immunohistochemistry / methods
  • Lymphangiogenesis*
  • Lymphatic Metastasis
  • Lymphatic Vessels / immunology
  • Lymphatic Vessels / pathology*
  • Middle Aged
  • Uterine Cervical Neoplasms / pathology*
  • Vascular Endothelial Growth Factor C / metabolism*

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • VEGFC protein, human
  • Vascular Endothelial Growth Factor C
  • monoclonal antibody D2-40