Background: The relationship between statins and cognition in Parkinson's disease (PD) is poorly understood.
Objectives: Analyses were performed to determine associations between statin use and cross-sectional and longitudinal cognitive performance in PD.
Methods: Neuropsychological tests, medication logs, and ratings of functional abilities were collected from 313 PD participants longitudinally.
Results: At baseline, statin users (SU; N = 129) were older, more likely male, and had shorter PD duration than non-statin users (NSU; N = 184). In Cross-sectional analysis, SU performed better on global cognition, Trails B, semantic fluency, and phonemic fluency tasks. Rate of long-term global cognitive (Dementia Rating Scale-2 and MoCA) decline was significantly less in SU.
Keywords: Apolipoprotein A-I; Parkinson’s disease; cognition; hydroxymethylglutaryl-CoA reductase inhibitors; longitudinal studies; reactive oxygen species.