Molecular mechanisms of LKB1 induced cell cycle arrest

Dian-Sheng Zhong; Lin-Lin Sun; Li-Xia Dong

doi:10.1111/1759-7714.12003

Molecular mechanisms of LKB1 induced cell cycle arrest

Thorac Cancer. 2013 Aug;4(3):229-233. doi: 10.1111/1759-7714.12003.

Authors

Dian-Sheng Zhong^{1

2}, Lin-Lin Sun², Li-Xia Dong¹

Affiliations

¹ Department of Respiratory Medicine, Tianjin Medical University General Hospital, Tianjin, China.
² Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.

PMID: 28920233
DOI: 10.1111/1759-7714.12003

Abstract

LKB1 is a serine/threonine protein kinase mutated in patients with Peutz-Jeghers syndrome. Biallelic inactivation of LKB1 is present in up to 30% of cases of non-small cell lung cancer (NSCLC). As a tumor suppressor, LKB1 functions in arresting the cell cycle and inhibiting cell growth. LKB1 leads to induction of p21/WAF1 expression in a p53-dependent mechanism, which is mediated by cytoplasmic LKB1 initiating negative regulation of cell growth or nuclear LKB1 directly involved in transcriptional regulation of p21/WAF1. Alternatively, p53 and p21/WAF1-independent mechanism of regulating cell cycle by LKB1 is also reported.

Keywords: LKB1; cell cycle; lung cancer; p21/WAF1; p53.

Publication types

Review