Resveratrol suppresses P-selectin, PSGL-1, and VWF through SIRT1 signaling pathway

Acta Biochim Biophys Sin (Shanghai). 2017 Sep 1;49(9):848-850. doi: 10.1093/abbs/gmx077.

Authors

Zhenkai Lou¹, Kaili Du¹, Tingting Wang², Xueling Zhao¹, Xingguo Li¹, Bing Wang¹

Affiliations

¹ Department of Orthopaedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
² Department of Geriatric medicine, The Affiliated Yan'an Hospital of Kunming Medical University, Kunming 650051, China.

PMID: 28910974
DOI: 10.1093/abbs/gmx077

No abstract available

MeSH terms

Antioxidants / pharmacology
Carbazoles / pharmacology
Cells, Cultured
Gene Expression / drug effects
Human Umbilical Vein Endothelial Cells / drug effects
Human Umbilical Vein Endothelial Cells / metabolism
Humans
Hydrogen Peroxide / pharmacology
Membrane Glycoproteins / genetics
Membrane Glycoproteins / metabolism*
Oxidants / pharmacology
P-Selectin / genetics
P-Selectin / metabolism*
Resveratrol
Signal Transduction / drug effects*
Signal Transduction / genetics
Sirtuin 1 / antagonists & inhibitors
Sirtuin 1 / genetics
Sirtuin 1 / metabolism*
Stilbenes / pharmacology*
von Willebrand Factor / genetics
von Willebrand Factor / metabolism*

Substances

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Antioxidants
Carbazoles
Membrane Glycoproteins
Oxidants
P-Selectin
P-selectin ligand protein
Stilbenes
von Willebrand Factor
Hydrogen Peroxide
SIRT1 protein, human
Sirtuin 1
Resveratrol