Double-Mutated 5-Enol Pyruvylshikimate-3-phosphate Synthase Protein Expressed in MZHG0JG Corn (Zea mays L.) Has No Impact on Toxicological Safety and Nutritional Composition

J Agric Food Chem. 2017 Sep 27;65(38):8459-8465. doi: 10.1021/acs.jafc.7b02217. Epub 2017 Sep 19.

Abstract

MZHG0JG corn will offer growers the flexibility to alternate between herbicides with two different modes of action in their weed-management programs, helping to mitigate and manage the evolution of herbicide resistance in weed populations. The proteins conferring herbicide tolerence in MZHG0JG corn, double-mutated 5-enol pyruvylshikimate-3-phosphate synthase protein (mEPSPS) and phosphinothricin acetyltransferase (PAT), as well as the MZHG0JG corn event, have been assessed by regulatory authorities globally and have been determined to be safe for humans, animals, and the environment. In addition to the safety data available for these proteins, further studies were conducted on MZHG0JG corn to assess levels of mEPSPS as compared to previously registered genetically modified (GM) corn. The results support the conclusion of no impact on toxicological safety or nutritional composition.

Keywords: MZHG0JG; PAT; Zea mays L.; corn; genetically modified; mEPSPS.

MeSH terms

  • 3-Phosphoshikimate 1-Carboxyvinyltransferase / genetics*
  • 3-Phosphoshikimate 1-Carboxyvinyltransferase / metabolism
  • Acetyltransferases / genetics*
  • Acetyltransferases / metabolism
  • Agrobacterium tumefaciens / enzymology
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Hazard Analysis and Critical Control Points
  • Herbicide Resistance
  • Herbicides / pharmacology
  • Mutation
  • Nutritive Value
  • Plants, Genetically Modified / adverse effects
  • Plants, Genetically Modified / drug effects
  • Plants, Genetically Modified / genetics*
  • Plants, Genetically Modified / metabolism
  • Streptomyces / enzymology
  • Zea mays / adverse effects
  • Zea mays / drug effects
  • Zea mays / genetics*
  • Zea mays / metabolism

Substances

  • Bacterial Proteins
  • Herbicides
  • Acetyltransferases
  • phosphinothricin N-acetyltransferase
  • 3-Phosphoshikimate 1-Carboxyvinyltransferase