[Lung dose constraints for normo-fractionated radiotherapy and for stereotactic body radiation therapy]

Abstract

Radiation-induced lung disease (RILD) is common after radiation therapy and represents cornerstone toxicities after treatment of thoracic malignancies. From a review of literature, the objective of this article was to summarize clinical and non-clinical parameters associated with the risk of RILD in the settings of normo-fractionated radiotherapy and stereotactic body radiation therapy (SBRT). For the treatment of lung cancers with a normo-fractionated treatment, the mean lung dose (MLD) should be below 15-20Gy. For a thoracic SBRT, V20Gy<10% and MLD<6Gy are recommended. One should pay attention to central tumors and respect specific dose constraints to the bronchial tree. The recent technological improvements may represent an encouraging way to decrease lung toxicities. Finally, our team developed a calculator in order to predict the risk of radiation pneumonitis.

Keywords: Dose constraints; Doses de tolérance; Lung; Normo-fractionated radiotherapy; Organ at risk; Organe à risque; Poumons; Radiothérapie conformationnelle; Radiothérapie stéréotaxique; Stereotactic body radiation therapy.