SnapShot: Connexins and Disease

Dale W Laird; Christian C Naus; Paul D Lampe

doi:10.1016/j.cell.2017.08.034

SnapShot: Connexins and Disease

Cell. 2017 Sep 7;170(6):1260-1260.e1. doi: 10.1016/j.cell.2017.08.034.

Authors

Dale W Laird¹, Christian C Naus², Paul D Lampe³

Affiliations

¹ Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada.
² Department of Cellular & Physiological Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
³ Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

PMID: 28886388
DOI: 10.1016/j.cell.2017.08.034

Abstract

The connexin family of membrane proteins enable gap junction formation and homeostasis, supporting communication between adjacent cells. This SnapShot highlights mutations in different connexins associated with human pathologies and how they affect gap junction function.

MeSH terms

Connexins / chemistry
Connexins / genetics
Connexins / metabolism*
Disease / genetics*
Gap Junctions
Humans
Mutation

Substances

Connexins

Grants and funding

R01 GM055632/GM/NIGMS NIH HHS/United States