Abstract
The last three decades have shown that the fungi can be 'biofactories' of novel, bioactive secondary metabolites that produce numerous natural products with novel skeletons and biological activities. Particularly in the last 10 years, large numbers of antimicrobial fungal secondary metabolites have been discovered. This review provides an overview of key, defining developments of the last 10 years regarding the discovery of antimicrobial activity, chemotaxonomy and chemodiversity of fungal polyketides.
Keywords:
biodiversity; chemodiversity; fungi; polyketides.
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification
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Anthraquinones / pharmacology
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Benzophenones / chemistry
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Benzophenones / isolation & purification
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Benzophenones / pharmacology
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Coumarins / chemistry
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Coumarins / isolation & purification
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Coumarins / pharmacology
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Depsides / chemistry
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Depsides / isolation & purification
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Depsides / pharmacology
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Fungi / chemistry*
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Fungi / metabolism
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology
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Polyketides / chemistry*
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Polyketides / isolation & purification
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Polyketides / pharmacology
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Pyrones / chemistry
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Pyrones / isolation & purification
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Pyrones / pharmacology
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Xanthones / chemistry
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Xanthones / isolation & purification
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Xanthones / pharmacology
Substances
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Anthraquinones
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Anti-Infective Agents
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Benzophenones
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Coumarins
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Depsides
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Lactones
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Polyketides
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Pyrones
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Xanthones
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depsidone
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benzophenone