Review of Protocols Used in Ultrasound Thrombolysis

Nicos Papadopoulos; Panayiotis A Kyriacou; Christakis Damianou

doi:10.1016/j.jstrokecerebrovasdis.2017.07.032

Review of Protocols Used in Ultrasound Thrombolysis

J Stroke Cerebrovasc Dis. 2017 Nov;26(11):2447-2469. doi: 10.1016/j.jstrokecerebrovasdis.2017.07.032. Epub 2017 Sep 4.

Authors

Nicos Papadopoulos¹, Panayiotis A Kyriacou¹, Christakis Damianou²

Affiliations

¹ Research Centre for Biomedical Engineering, City, University of London, UK.
² Electrical Engineering Department, Cyprus University of Technology, Cyprus. Electronic address: christakis.damianou@cut.ac.cy.

PMID: 28882659
DOI: 10.1016/j.jstrokecerebrovasdis.2017.07.032

Abstract

Objectives: This paper focuses on the review of protocols used in thrombolysis studies with ultrasound.

Materials and methods: Data from peer-review articles were acquired.

Results: The protocols of several published reports are summarized in 3 tables (in vitro, in vivo, and clinical), providing detailed information concerning clot model, thrombolytic drug, treatment mode, sonication parameters, evaluation method, thrombolysis outcome, side effects, and conclusions.

Conclusions: The aim of this review was to give an overview of the different protocols used so far in the field of sonothrombolysis and investigate the impact of several aspects involved on sonothrombolysis outcome.

Keywords: MRI; Stroke; clot; thrombus; ultrasound.

Publication types

Review

MeSH terms

Animals
Humans
PubMed / statistics & numerical data
Thromboembolism / therapy*
Thrombolytic Therapy / methods*
Ultrasonic Therapy / methods*