Coumarins and alkaloids from the roots of Toddalia asiatica

Sanwat Sukieum; Wichien Sang-Aroon; Chavi Yenjai

doi:10.1080/14786419.2017.1374264

Coumarins and alkaloids from the roots of Toddalia asiatica

Nat Prod Res. 2018 Apr;32(8):944-952. doi: 10.1080/14786419.2017.1374264. Epub 2017 Sep 7.

Authors

Sanwat Sukieum¹, Wichien Sang-Aroon², Chavi Yenjai¹

Affiliations

¹ a Natural Products Research Unit, Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
² b Faculty of Engineering, Department of Chemistry , Rajamangala University of Technology Isan , Khon Kaen , Thailand.

PMID: 28880112
DOI: 10.1080/14786419.2017.1374264

Abstract

The EtOAc and MeOH extracts of the roots of Toddalia asiatica Lam. were investigated for the roots' chemical constituents. Two new compounds including 2'R-acetoxytoddanol (1) and 8S-10-O-demethylbocconoline (3) as well as 15 known compounds were isolated. Compound 10 showed strong cytotoxicity against KB cells with an IC₅₀ value of 2.60 μg/mL, which is nearly equal to the ellipticine standard, but showed no activity against Vero cells. Alkaloid 3 displayed weak cytotoxicity against the KB cell line with an IC₅₀ value of 21.69 μg/mL.

Keywords: 2′R-Acetoxytoddanol; Toddalia asiatica; phenanthridine; quinolone alkaloid.

MeSH terms

Alkaloids / chemistry*
Alkaloids / pharmacology*
Animals
Cell Line, Tumor
Chlorocebus aethiops
Coumarins / chemistry*
Coumarins / pharmacology*
Humans
Inhibitory Concentration 50
KB Cells
Molecular Structure
Plant Extracts / chemistry
Plant Roots / chemistry
Rutaceae / chemistry*
Vero Cells

Substances

Alkaloids
Coumarins
Plant Extracts