Pathological scars,including keloids and hypertrophic scars,result from aberrations in the process of physiologic wound healing.An exaggerated inflammatory process is one of the main pathophysiological contributors.Pathological scars may cause pain and pruritis,limit joint mobility,and cause a range of cosmetic deformities that affect the patient's quality of life.However,the effectiveness of currently available prevention and treatment measures remains unsatisfactory.Mesenchymal stem cells,among their multifunctional roles,have the functions of immunomodulation and promotion of angiogenesis.Thus,they have been proposed to be a major candidate for cell therapy to treat or prevent pathologicalscars.This article reviews the mechanism and potentials of stem cell therapy in the prevention and treatment of pathological scars.
病理性瘢痕,包括增生性瘢痕和瘢痕疙瘩,是皮肤创伤后组织异常修复的结果。炎症反应是促进病理性瘢痕形成的主要原因。病理性瘢痕常引起瘙痒、疼痛、关节活动受限和畸形,进而影响到患者的生活质量。目前常用的治疗方法效果并不理想。间充质干细胞因具有多向分化潜能、免疫调节及促血管形成作用,可影响瘢痕的形成及发展,作为一种细胞治疗方法有望用来预防及治疗病理性瘢痕,已成为近期研究热点。本文主要综述间充质干细胞预防及治疗病理性瘢痕机制方面的最新进展。.