TRPM2: Shredding the mitochondrial network

Fangfang Li; Nada Abuarab; Asipu Sivaprasadarao

doi:10.1080/19336950.2017.1376982

TRPM2: Shredding the mitochondrial network

Channels (Austin). 2017 Nov 2;11(6):507-509. doi: 10.1080/19336950.2017.1376982. Epub 2017 Oct 5.

Authors

Fangfang Li¹, Nada Abuarab¹, Asipu Sivaprasadarao^{1

2}

Affiliations

¹ a School of Biomedical Sciences , Faculty of Biological Sciences, University of Leeds , Leeds , UK.
² b Multidisciplinary Cardiovascular Research Centre , University of Leeds , Leeds , UK.

No abstract available

Keywords: TRPM2; calcium; diabetes; fatty acid; mitochondrial dynamics; obesity; oxidative stress; pancreatic β-cell death; reactive oxygen species; zinc.

MeSH terms

Apoptosis / drug effects
Calcium / metabolism
Calcium Channels / drug effects
Cations, Divalent / metabolism
Dynamins
Fatty Acids / metabolism
GTP Phosphohydrolases / metabolism
Humans
Insulin-Secreting Cells / cytology
Lysosomes / metabolism
Microtubule-Associated Proteins / metabolism
Mitochondria / drug effects*
Mitochondrial Dynamics / drug effects*
Mitochondrial Proteins / metabolism
Reactive Oxygen Species / metabolism
Signal Transduction*
TRPM Cation Channels / antagonists & inhibitors*
Zinc / metabolism*

Substances

Calcium Channels
Cations, Divalent
Fatty Acids
Microtubule-Associated Proteins
Mitochondrial Proteins
Reactive Oxygen Species
TRPM Cation Channels
TRPM2 protein, human
GTP Phosphohydrolases
DNM1L protein, human
Dynamins
Zinc
Calcium