Copper-Catalyzed Synthesis and Applications of Yndiamides

Abstract

The first synthetic route to yndiamides, a novel class of double aza-substituted alkyne, has been established by the copper(I)-catalyzed cross-coupling of 1,1-dibromoenamides with nitrogen nucleophiles. The utility of these compounds is demonstrated in a range of transition-metal-catalyzed and acid-catalyzed transformations to afford a wide variety of 1,2-diamide functionalized products.

Keywords: copper catalysis; cycloisomerization; heterocycles; ynamides; yndiamides.