Tumor Budding in Oral Squamous Cell Carcinoma

J Contemp Dent Pract. 2017 Sep 1;18(9):743-744. doi: 10.5005/jp-journals-10024-2118.

Abstract

Tumor budding is defined as the presence of a single tumor cell or a small cluster of up to five cells in the tumor stroma, linking it to the epithelial-mesenchymal transition (EMT).1 Imai2 illustrated that tumors with this trait have more aggressive qualities and allocated the term "sprouting" instead of "budding." The term "tumor budding" was coined by Morodomi et al in 1989.3 Tumor budding in vitro or in experiments has been addressed by many names, depending on the researcher's background, few of which are tumor cell dissociation, focal dedifferentia-tion, or EMT.4.

Publication types

  • Editorial

MeSH terms

  • Carcinoma, Squamous Cell / pathology*
  • Epithelial-Mesenchymal Transition
  • Humans
  • Mouth Neoplasms / pathology*