Objective To investigate the distribution characteristics of polymorphisms of rs848G/T and rs1295686A/G in the interleukin 13 (IL-13) gene in Guangxi normal people and compare them with those of Europeans, Beijing peoples, Japanese and Africans published in HapMap. Methods The rs848G/T and rs1295686A/G of IL-13 gene in 275 cases of Guangxi people were genotyped by SNaPshot and DNA sequencing. The differences between groups were analyzed statistically. Results Three genotypes, namely GG, GT and TT, were found in rs848G/T with frequency distributions of 38.2%, 47.3% and 14.5%, respectively. There was no significant difference in each genotype and allele frequency between different genders in Guangxi people. However, there were significant differences in the genotype frequency of rs848G/T in Guangxi people compared with those of Europeans, Japanese and Africans published in HapMap. The allele frequency of rs848G/T between Guangxi people and the other four groups was statistically different. Three genotypes, namely AA, AG and GG, were found in rs1295686A/G with frequency distributions of 11.6%, 46.2% and 42.2%, respectively. There was no significant difference in the genotypes and allele frequency in rs1295686A/G between different genders in Guangxi people, while they were statistically different from those of Europeans and Africans published in HapMap. Conclusion There are different degrees of variance in the polymorphisms of rs848G/T and rs1295686A/G of IL-13 gene in different regions.