Abnormalities of T-cell receptor repertoire in CD4⁺ regulatory and conventional T cells in patients with RAG mutations: Implications for autoimmunity

Affiliations

• ¹ Division of Immunology, Boston Children's Hospital, Boston, Mass.
• ² Department of Pathology, University of Massachusetts Medical School, Worcester, Mass.
• ³ Pediatric Department A and the Immunology Service, "Edmond and Lily Safra" Children's Hospital, Jeffrey Modell Foundation Center, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
• ⁴ Division of Allergy and Immunology, University of Texas, Southwestern Medical Center, Dallas, Tex.
• ⁵ Division of Hematology/Oncology/BMT, Children's Mercy Hospital & Clinics, Kansas City, Mo.
• ⁶ Department of Pediatrics, Brown University, Providence, RI.
• ⁷ Department of Pediatrics, National University of Singapore, Singapore.
• ⁸ Department of Immunology-Histocompatibility, "Aghia Sophia" Children's Hospital, Athens, Greece.
• ⁹ Division of Pediatric Immunology, Hospital Luis Calvo Mackenna, Santiago, Chile.
• ¹⁰ Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
• ¹¹ Pediatric Hematology-Immunology Department, Hospital Necker-Enfants Malades, AP-HP, Paris Descartes University, Sorbonne-Paris-Cité, Institut Imagine, Paris, France.
• ¹² Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St Petersburg, Fla.
• ¹³ Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: luigi.notarangelo2@nih.gov.