Graphene oxide as a catalyst for the diastereoselective transfer hydrogenation in the synthesis of prostaglandin derivatives

Simona M Coman; Iunia Podolean; Madalina Tudorache; Bogdan Cojocaru; Vasile I Parvulescu; Marta Puche; Hermenegildo Garcia

doi:10.1039/c7cc05105k

Graphene oxide as a catalyst for the diastereoselective transfer hydrogenation in the synthesis of prostaglandin derivatives

Chem Commun (Camb). 2017 Sep 14;53(74):10271-10274. doi: 10.1039/c7cc05105k.

Authors

Simona M Coman¹, Iunia Podolean, Madalina Tudorache, Bogdan Cojocaru, Vasile I Parvulescu, Marta Puche, Hermenegildo Garcia

Affiliation

¹ Department of Organic Chemistry, Biochemistry and Catalysis, Chemistry, University of Bucharest, Bdul Regina Elisabeta 4-12, Bucharest 030016, Romania. vasile.parvulescu@chimie.unibuc.ro.

PMID: 28862277
DOI: 10.1039/c7cc05105k

Abstract

Modification of GO by organic molecules changes its catalytic activity in the hydrogen transfer from i-propanol to enones, affecting the selectivity to allyl alcohol and diastereoselectivity to the resulting stereoisomers. It is noteworthy the system does not contain metals and is recyclable.

MeSH terms

Catalysis
Graphite / chemistry*
Hydrogenation
Molecular Structure
Oxides / chemistry*
Prostaglandins / chemical synthesis*
Prostaglandins / chemistry
Stereoisomerism

Substances

Oxides
Prostaglandins
Graphite