Viscoelastic dynamic arterial response

Abstract

Background: Arteries undergo large deformations under applied intraluminal pressure and may exhibit small hysteresis due to creep or relaxation process. The mechanical response of arteries depends, among others, on their topology along the arterial tree. Viscoelasticity of arterial tissues, which is the topic investigated in this study, is mainly a characteristic mechanical response of arteries that are located away from the heart and have increased smooth muscle cells content.

Methods: The arterial wall viscosity is simulated by adopting a generalized Maxwell model and the method of internal variables, as proposed by Bonet and Holzapfel et al. The total stresses consist of elastic long-term stresses and viscoelastic stresses, requiring an iterative procedure for their calculation. The cross-section of the artery is modeled as a circular ring, consisting of a single homogenized layer, under a time-varying blood pressure. Two different loading approximations for the aortic pressure vs time are considered. A novel numerical method is developed in order to solve the controlling integro-differential equation.

Results: A large number of numerical investigations are performed and typical response time-profiles are presented in pictorial form. Results suggest that the viscoelastic arterial response is mainly affected by the ratio of the relaxation time to the characteristic time of the response and by the pressure-time approximation. Numerical examples, based on data available in the literature, are conducted.

Conclusions: The investigation presented in this study reveals the effect of each material parameter on the viscoelastic arterial response. Thus, a better understanding of the behavior of viscoelastic arteries is achieved.

Keywords: Dynamic analysis; Human arteries; Total-energy density; Viscoelastic arterial model.