Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor

Cell Res. 2017 Oct;27(10):1289-1292. doi: 10.1038/cr.2017.111. Epub 2017 Aug 29.

Authors

Lijie Wang^{1

2

3}, Wei Xue⁴, Lei Yan^{1

2

3

5}, Xiaosa Li^{1

2

3}, Jia Wei⁴, Miaomiao Chen¹, Jing Wu¹, Bei Yang⁵, Li Yang⁴, Jia Chen¹

Affiliations

¹ School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
² Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.
³ University of Chinese Academy of Sciences, Beijing 100049, China.
⁴ Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
⁵ Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

CRISPR-Associated Protein 9 / genetics
DNA Repair / genetics*
Gene Editing / methods*
HEK293 Cells
HeLa Cells
Humans
INDEL Mutation
Uracil-DNA Glycosidase / antagonists & inhibitors*
Uracil-DNA Glycosidase / genetics*

Substances

CRISPR-Associated Protein 9
Uracil-DNA Glycosidase