RETRACTED: miR-367 regulation of DOC-2/DAB2 interactive protein promotes proliferation, migration and invasion of osteosarcoma cells

Biomed Pharmacother. 2017 Nov:95:120-128. doi: 10.1016/j.biopha.2017.07.158. Epub 2017 Sep 12.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors, who have informed the Editor-in-Chief that miR-367 overexpression did not significantly reduce the DAB2IP level in MG-63 cells as shown in Figures 4C and 4D of the published article. Furthermore, the effects of miR-367 overexpression and DAB2IP knockdown on the proliferation and metastasis of MG-63 cells in Figure 2 and Figure 6 are also no longer repeatable. Subsequent analysis showed that the MG-63 cells used in this study were contaminated with HeLa cells, identified by short tandem repeat analysis. The authors believe cell contamination may be the main reason why the reported results are not reproducible. The authors no longer have confidence in the reliability of the results and would like to apologize for any inconvenience caused. The Editor-in-Chief agreed to retract the article.

Keywords: DOC-2/DAB2 interactive protein; Metastasis; Osteosarcoma; Tumor growth; microRNA-367.

Publication types

  • Retracted Publication

MeSH terms

  • Bone Neoplasms / metabolism*
  • Bone Neoplasms / pathology
  • Cell Proliferation / physiology
  • Gene Expression Regulation, Neoplastic*
  • Gene Knockdown Techniques
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Neoplasm Invasiveness*
  • Osteosarcoma / metabolism*
  • Osteosarcoma / pathology
  • ras GTPase-Activating Proteins / genetics
  • ras GTPase-Activating Proteins / metabolism*

Substances

  • DAB2IP protein, human
  • MIRN367 microRNA, human
  • MicroRNAs
  • ras GTPase-Activating Proteins