Navigating the Cancer Transcriptome by Decoding Divergent Oncogenic States

Samirkumar B Amin; Roel G W Verhaak

doi:10.1016/j.cels.2017.08.006

Navigating the Cancer Transcriptome by Decoding Divergent Oncogenic States

Cell Syst. 2017 Aug 23;5(2):90-92. doi: 10.1016/j.cels.2017.08.006.

Authors

Samirkumar B Amin¹, Roel G W Verhaak²

Affiliations

¹ The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06032, USA.
² The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06032, USA. Electronic address: roel.verhaak@jax.org.

PMID: 28837814
DOI: 10.1016/j.cels.2017.08.006

Abstract

A new approach decomposes aberrant signaling mediated by an oncogenic mutation into underlying core cellular states that may be more permissive to available therapeutic options.

Publication types

Comment

MeSH terms

Carcinogenesis
Cell Line, Tumor
Humans
Mutation
Oncogenes*
Transcriptome*

Grants and funding

P30 CA034196/CA/NCI NIH HHS/United States