Malaria, metabolism and mathematical models

FEBS J. 2017 Aug;284(16):2553-2555. doi: 10.1111/febs.14161.

Abstract

Understanding the dynamic behaviour of the Plasmodium falciparum metabolism during infection can help identify targets for drug development. In this Commentary, we highlight recently published studies in The FEBS Journal that cover mathematical modelling of glycolysis in P. falciparum and the identification and in vivo validation of metabolic drug targets.

MeSH terms

  • Antimalarials / pharmacology
  • Antimalarials / therapeutic use*
  • Glycolysis / drug effects
  • Humans
  • Malaria / drug therapy*
  • Models, Theoretical*
  • Plasmodium falciparum / drug effects
  • Plasmodium falciparum / metabolism

Substances

  • Antimalarials