Review of triazine antiprotozoal drugs used in veterinary medicine

M L Stock; S T Elazab; W H Hsu

doi:10.1111/jvp.12450

Review of triazine antiprotozoal drugs used in veterinary medicine

J Vet Pharmacol Ther. 2018 Apr;41(2):184-194. doi: 10.1111/jvp.12450. Epub 2017 Aug 17.

Authors

M L Stock¹, S T Elazab^{1

2}, W H Hsu¹

Affiliations

¹ Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
² Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, El-Mansoura, Egypt.

PMID: 28833212
DOI: 10.1111/jvp.12450

Abstract

Triazines are relatively new antiprotozoal drugs that have successfully controlled coccidiosis and equine protozoal myeloencephalitis. These drugs have favorably treated other protozoal diseases such as neosporosis and toxoplasmosis. In this article, we discuss the pharmacological characteristics of five triazines, toltrazuril, ponazuril, clazuril, diclazuril, and nitromezuril which are used in veterinary medicine to control protozoal diseases which include coccidiosis, equine protozoal myeloencephalitis, neosporosis, and toxoplasmosis.

Publication types

Review

MeSH terms

Acetonitriles / therapeutic use
Animals
Antiprotozoal Agents / therapeutic use*
Coccidiosis / drug therapy
Coccidiosis / veterinary
Encephalomyelitis, Equine / drug therapy
Encephalomyelitis, Equine / parasitology
Encephalomyelitis, Equine / veterinary
Horses
Nitriles / therapeutic use
Protozoan Infections, Animal / drug therapy*
Toxoplasmosis, Animal / drug therapy
Triazines / therapeutic use*

Substances

2-(3-methyl-4-(4-nitrophenoxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione
Acetonitriles
Antiprotozoal Agents
Nitriles
Triazines
ponazuril
diclazuril
clazuril
toltrazuril