PSEN1 gene polymorphisms in Caucasian Alzheimer's disease: A meta-analysis

V Ramakrishnan; R S Akram Husain; Shiek S S J Ahmed

doi:10.1016/j.cca.2017.08.016

PSEN1 gene polymorphisms in Caucasian Alzheimer's disease: A meta-analysis

Clin Chim Acta. 2017 Oct:473:65-70. doi: 10.1016/j.cca.2017.08.016. Epub 2017 Aug 15.

Authors

V Ramakrishnan¹, R S Akram Husain¹, Shiek S S J Ahmed²

Affiliations

¹ Genetics Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, India.
² Drug Discovery Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, India. Electronic address: shiekssjahmed@gmail.com.

PMID: 28821390
DOI: 10.1016/j.cca.2017.08.016

Abstract

Background: A meta-analysis was performed to assess PSEN1 gene polymorphisms (rs1800839 and rs17125721) in Alzheimer's disease (AD) risk.

Methods: A systematic electronic search was performed across databases to retrieve studies published before 31 January 2017. The association between the selected PSEN1 polymorphisms and AD was based on five genetic models using DerSimonian and Laird's method or Mantel-Haenszel's method.

Results: A total of 14 case-controlled studies were included. Results showed that rs1800839 polymorphism was significantly associated with AD in allelic OR=0.85 (95% CI [0.72-1.00]) and dominant OR=0.82 (95% CI [0.69-0.98]) genetic models, respectively. However, an insignificant association was found for rs17125721 polymorphism in all genetic models.

Conclusions: Meta-analysis of PSEN1 gene suggests that the rs1800839 polymorphism has potential influence on AD among Caucasians.

Keywords: Alzheimer's disease; Genetic models; Meta-analysis; PSEN1; Polymorphism.

Publication types

Meta-Analysis

MeSH terms

Alzheimer Disease / genetics*
Humans
Polymorphism, Genetic*
Presenilin-1 / genetics*
White People / genetics*

Substances

PSEN1 protein, human
Presenilin-1