Abstract
In 2011, a group A rotavirus was isolated from the brain of a fox with encephalitis and neurologic signs, detected by rabies surveillance in Italy. Intracerebral inoculation of fox brain homogenates into mice was fatal. Genome sequencing revealed a heterologous rotavirus of avian origin, which could provide a model for investigating rotavirus neurovirulence.
Keywords:
Italy; brain; fox; group A rotavirus; meningitis/encephalitis; neurologic disease; rotavirus; viruses.
MeSH terms
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Animals
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Animals, Suckling
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Brain / pathology
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Brain / virology
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Columbidae / virology*
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Encephalitis / epidemiology
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Encephalitis / pathology
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Encephalitis / veterinary*
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Encephalitis / virology
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Epidemiological Monitoring
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Foxes / virology*
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Genome, Viral*
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Italy / epidemiology
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Mice
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Phylogeny
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Rotavirus / classification
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Rotavirus / genetics
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Rotavirus / isolation & purification
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Rotavirus Infections / epidemiology
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Rotavirus Infections / transmission
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Rotavirus Infections / veterinary*
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Rotavirus Infections / virology
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Weaning