Making It Personal: Neoantigen Vaccines in Metastatic Melanoma

Immunity. 2017 Aug 15;47(2):221-223. doi: 10.1016/j.immuni.2017.08.001.

Abstract

Somatic mutations in cancer can be translated into peptides, termed neoantigens, which can be recognized by the immune system as "foreign" epitopes. Two recent studies in Nature (Sahin et al., 2017; Ott et al., 2017) examine the effects of neoantigen vaccines on patients with stage III or IV melanoma and demonstrate immunogenicity and intriguing clinical safety and efficacy data in phase I studies.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigens, Neoplasm / genetics
  • Antigens, Neoplasm / immunology*
  • Autoantigens / genetics
  • Cancer Vaccines / immunology*
  • Clinical Trials, Phase I as Topic
  • Humans
  • Immunotherapy / methods*
  • Melanoma / immunology
  • Melanoma / pathology
  • Melanoma / therapy*
  • Mutation / genetics
  • Neoplasm Metastasis
  • Skin Neoplasms / immunology
  • Skin Neoplasms / pathology
  • Skin Neoplasms / therapy*
  • Vaccines, Subunit

Substances

  • Antigens, Neoplasm
  • Autoantigens
  • Cancer Vaccines
  • Vaccines, Subunit