Screening performance for callosal agenesis in prenatal life. Single center study

Clin Imaging. 2017 Nov-Dec:46:116-120. doi: 10.1016/j.clinimag.2017.07.018. Epub 2017 Aug 1.

Abstract

Objectives: 1) To analyze screening performance of second trimester scan for ACC, 2) to evaluate the agreement between ultrasound and MRI and 3) to compare prenatal and postnatal diagnosis.

Methods: It was a prospective observational study. All patients with fetuses suspected of ACC were referred to prenatal MRI (pMRI).

Results: One subject was not confirmed by pMRI with the diagnosis of ACC. This case demonstrated partial ACC in neonatal MRI (nMRI).

Conclusion: Sensitivity of second trimester scan for callosal agenesis of 73% and specificity of 99%. Prenatal MRI and US has similar amount of misdiagnoses.

Keywords: Agenesis; Callosal; Prenatal magnetic resonance imaging; Screening; Ultrasound.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Agenesis of Corpus Callosum / diagnosis*
  • Agenesis of Corpus Callosum / diagnostic imaging
  • Diagnostic Errors
  • Female
  • Humans
  • Infant, Newborn
  • Magnetic Resonance Imaging / methods*
  • Middle Aged
  • Pregnancy
  • Pregnancy Trimester, Second
  • Prenatal Diagnosis / standards*
  • Prospective Studies
  • Sensitivity and Specificity
  • Ultrasonography / methods*
  • Ultrasonography, Prenatal
  • Young Adult