Clinical outcome of dual colistin- and carbapenem-resistant Klebsiella pneumoniae bloodstream infections: A single-center retrospective study of 75 cases in India

Am J Infect Control. 2017 Nov 1;45(11):1289-1291. doi: 10.1016/j.ajic.2017.06.028. Epub 2017 Aug 12.

Abstract

In this study, we retrospectively evaluated clinical outcomes of 75 patients with dual colistin- and carbapenem-resistant Klebsiella pneumoniae bloodstream infections over a 5-year period in a single tertiary care hospital in India. We observed a high in-hospital mortality rate of 69.3%. Our findings indicate the urgent need for new antibiotics to treat these infections.

Keywords: Carbapenem resistance; Colistin resistance; India; Klebsiella.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Bacteremia / drug therapy
  • Bacteremia / microbiology*
  • Carbapenem-Resistant Enterobacteriaceae / drug effects
  • Carbapenems / therapeutic use*
  • Colistin / therapeutic use*
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Humans
  • India / epidemiology
  • Klebsiella Infections / drug therapy*
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae* / drug effects
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Colistin