IncX3 plasmid harboring a non-Tn4401 genetic element (NTEKPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258

Diagn Microbiol Infect Dis. 2017 Oct;89(2):164-167. doi: 10.1016/j.diagmicrobio.2017.06.022. Epub 2017 Jul 1.

Abstract

IncX-type plasmids have achieved clinical significance for their contribution in the dissemination of genes confering resistance to carbapenems (most blaKPC- and blaNDM-type genes) and polymyxins (mcr-type genes), both antibiotics considered last resort for multidrug-resistant Gram-negative infections. In this study, we report the identification and complete sequence analysis of an IncX3 plasmid (designated pKP1194a) carrying a non-Tn4401 genetic element (NTEKPC) of tnpR-tnpA (partial)-blaKPC-2-ΔISKpn6/traN, originating from a hospital-associated lineage of K. pneumoniae belonging to the ST340/CG258, with epidemiological link to Brazil.

Keywords: Brazil; CC258; Carbapenemase; IncX3; KPC-2; Klebsiella pneumoniae.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Base Sequence
  • Carbapenems / therapeutic use
  • Cross Infection / microbiology
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Humans
  • Interspersed Repetitive Sequences / genetics*
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics*
  • Microbial Sensitivity Tests
  • Plasmids / genetics*
  • Polymyxins / therapeutic use
  • Sequence Analysis, DNA
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Polymyxins
  • beta-Lactamases
  • beta-lactamase KPC-2, Klebsiella pneumoniae