Two Furanosesterterpenoids from the Sponge Luffariella variabilis

Peni Ahmadi; Masahiro Higashi; Nicole J de Voogd; Junichi Tanaka

doi:10.3390/md15080249

Two Furanosesterterpenoids from the Sponge Luffariella variabilis

Mar Drugs. 2017 Aug 10;15(8):249. doi: 10.3390/md15080249.

Authors

Peni Ahmadi¹, Masahiro Higashi², Nicole J de Voogd³, Junichi Tanaka⁴

Affiliations

¹ Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan. peni.ahmadi@gmail.com.
² Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan. higashi@sci.u-ryukyu.ac.jp.
³ Naturalis Biodiversity Center, P.O. Box 9517, 2300 RA Leiden, The Netherlands. nicole.devoogd@naturalis.nl.
⁴ Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan. jtanaka@sci.u-ryukyu.ac.jp.

Abstract

Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC₅₀ 1.0 µM against NBT-T2 cells.

Keywords: cytotoxicity; sesterterpenoid; sponge.

MeSH terms

Animals
Cell Line
Furans / chemistry
Furans / isolation & purification*
Humans
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera / chemistry*
Sesterterpenes / chemistry
Sesterterpenes / isolation & purification*

Substances

Furans
Sesterterpenes