1 Department of Surgery and Cancer, Anaesthetics, Pain Medicine and Intensive Care Section, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom; Department of Anaesthetics, The Queen Elizabeth Hospital, Birmingham, United Kingdom; Preclinical Compound Profiling, Secondary Pharmacology, Preclinical Safety, NIBR, Cambridge, Massachusetts; Department of Molecular Cell Biology, Campus Gasthuisberg, Leuven, Belgium; School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.