Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity

Daniel P Neumann; Gregory J Goodall; Philip A Gregory

doi:10.1016/j.semcdb.2017.08.008

Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity

Semin Cell Dev Biol. 2018 Mar:75:50-60. doi: 10.1016/j.semcdb.2017.08.008. Epub 2017 Aug 5.

Authors

Daniel P Neumann¹, Gregory J Goodall², Philip A Gregory³

Affiliations

¹ Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, 5000, Australia.
² Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, 5000, Australia; Discipline of Medicine, The University of Adelaide, Adelaide, SA 5005, Australia; School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA 5005, Australia.
³ Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, 5000, Australia; Discipline of Medicine, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: philip.gregory@unisa.edu.au.

PMID: 28789987
DOI: 10.1016/j.semcdb.2017.08.008

Abstract

Interconversions between epithelial and mesenchymal states, often referred to as epithelial mesenchymal transition (EMT) and its reverse MET, play important roles in embryonic development and are recapitulated in various adult pathologies including cancer progression. These conversions are regulated by complex transcriptional and post-transcriptional mechanisms including programs of alternative splicing which are orchestrated by specific splicing factors. This review will focus on the latest developments in our understanding of the splicing factors regulating epithelial mesenchymal plasticity associated with cancer progression and the induction of pluripotency, including potential roles for circular RNAs (circRNAs) which have been recently implicated in these processes.

Keywords: Alternative splicing; Circular RNA; Epithelial-mesenchymal transition.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alternative Splicing*
Animals
Epithelial-Mesenchymal Transition / genetics*
Gene Expression Regulation*
Humans
Models, Genetic
RNA / genetics*
RNA Isoforms / genetics
RNA Precursors / genetics
RNA Precursors / metabolism
RNA, Circular
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism

Substances

RNA Isoforms
RNA Precursors
RNA, Circular
RNA-Binding Proteins
RNA