Alginate-Collagen Fibril Composite Hydrogel

Mahmoud Baniasadi; Majid Minary-Jolandan

doi:10.3390/ma8020799

Alginate-Collagen Fibril Composite Hydrogel

Materials (Basel). 2015 Feb 16;8(2):799-814. doi: 10.3390/ma8020799.

Authors

Mahmoud Baniasadi¹, Majid Minary-Jolandan²

Affiliations

¹ Department of Mechanical Engineering, University of Texas at Dallas, 800 W. Campbell Rd, Richardson, TX 75080, USA. Mahmoud.Baniasadi@utdallas.edu.
² Department of Mechanical Engineering, University of Texas at Dallas, 800 W. Campbell Rd, Richardson, TX 75080, USA. majid.minary@utdallas.edu.

Abstract

We report on the synthesis and the mechanical characterization of an alginate-collagen fibril composite hydrogel. Native type I collagen fibrils were used to synthesize the fibrous composite hydrogel. We characterized the mechanical properties of the fabricated fibrous hydrogel using tensile testing; rheometry and atomic force microscope (AFM)-based nanoindentation experiments. The results show that addition of type I collagen fibrils improves the rheological and indentation properties of the hydrogel.

Keywords: AFM nanoindentation; alginate; composite hydrogel; mechanical properties; rheometry; tensile test; type I collagen fibril.