The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

Anticancer Agents Med Chem. 2018;18(6):769-775. doi: 10.2174/1871520617666170731115233.

Abstract

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine.

Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

Keywords: Plasma; cancer cells; cancer treatment; cold atmospheric plasma; reactive nitrogen species; reactive oxygen species..

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Atmospheric Pressure
  • Cell Proliferation / drug effects
  • Culture Media, Conditioned / chemistry
  • Culture Media, Conditioned / pharmacology*
  • Humans
  • Hydrogen Peroxide / chemistry
  • Hydrogen Peroxide / pharmacology*
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Nitrites / chemistry
  • Nitrites / pharmacology*
  • Plasma Gases*
  • Solutions

Substances

  • Antineoplastic Agents
  • Culture Media, Conditioned
  • Nitrites
  • Plasma Gases
  • Solutions
  • Hydrogen Peroxide