Abstract
Plasma is an ionized gas that is typically formed under high-temperature laboratory conditions. Recent progress in atmospheric plasmas has led to cold atmospheric plasma (CAP) devices with ion temperatures close to room temperature. The unique chemical and physical properties of CAP have led to its use in various biomedical applications including cancer therapy. CAP exhibits a spontaneous transition from a spatially homogeneous state to a modifiable pattern that is subject to self-organization. In this Opinion article, we discuss some new applications for plasma in cancer therapy based on plasma self-organization, which enables adaptive features in plasma-based therapeutic systems.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Antineoplastic Agents, Alkylating / pharmacology
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Aquaporins / genetics
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Aquaporins / metabolism
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Cell Line, Tumor
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Drug Resistance, Neoplasm / drug effects*
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Gene Expression
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Humans
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Melanoma / genetics
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Melanoma / metabolism
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Melanoma / pathology
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Melanoma / therapy*
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Mice
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Neurons / drug effects
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Neurons / metabolism
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Neurons / pathology
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Plasma Gases / therapeutic use*
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Precision Medicine / methods*
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Reactive Nitrogen Species / agonists
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Reactive Nitrogen Species / metabolism
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Reactive Oxygen Species / agonists
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Reactive Oxygen Species / metabolism
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Skin Neoplasms / genetics
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Skin Neoplasms / metabolism
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Skin Neoplasms / pathology
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Skin Neoplasms / therapy*
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Temozolomide / pharmacology
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Xenograft Model Antitumor Assays
Substances
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Antineoplastic Agents, Alkylating
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Aquaporins
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Plasma Gases
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Reactive Nitrogen Species
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Reactive Oxygen Species
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Temozolomide