Detection of Prostate Cancer Using a Multistep Approach with Prostate-specific Antigen, the Stockholm 3 Test, and Targeted Biopsies: The STHLM3 MRI Project

Tobias Nordström; Wolfgang Picker; Markus Aly; Fredrik Jäderling; Jan Adolfsson; Peter Ström; Erik Skaaheim Haug; Martin Eklund; Stefan Carlsson; Henrik Grönberg

doi:10.1016/j.euf.2017.01.014

Detection of Prostate Cancer Using a Multistep Approach with Prostate-specific Antigen, the Stockholm 3 Test, and Targeted Biopsies: The STHLM3 MRI Project

Eur Urol Focus. 2017 Dec;3(6):526-528. doi: 10.1016/j.euf.2017.01.014. Epub 2017 Mar 28.

Authors

Affiliations

¹ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden. Electronic address: tobias.nordstrom@ki.se.
² Department of Urology, Aleris Cancer Center, Oslo, Norway.
³ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Urology, Karolinska University Hospital Solna, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
⁴ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Diagnostic Radiology, Karolinska University Hospital, Stockholm, Sweden.
⁵ Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
⁶ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
⁷ Section of Urology, Vestfold Hospital Trust, Tønsberg, Norway.
⁸ Department of Urology, Karolinska University Hospital Solna, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

PMID: 28753850
DOI: 10.1016/j.euf.2017.01.014

Abstract

There is a distinct need for clinical improvements to the pipeline for prostate detection. The aim of the STHLM3 magnetic resonance imaging (MRI) study is to provide evidence of an improved and structured multistep pipeline for prostate cancer detection using the bloodbased Stockholm 3 test and MRI to achieve better specificity and reduce the risk of overdiagnosis.

Publication types

Clinical Trial Protocol
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Clinical Trials, Phase I as Topic
Clinical Trials, Phase II as Topic
Early Detection of Cancer
Humans
Image-Guided Biopsy
Magnetic Resonance Imaging, Interventional
Male
Middle Aged
Multicenter Studies as Topic
Prostate / pathology
Prostate-Specific Antigen / metabolism
Prostatic Neoplasms / diagnosis*
Randomized Controlled Trials as Topic

Substances

Prostate-Specific Antigen

Associated data

ISRCTN/ISRCTN84445406