CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection

J Med Primatol. 2017 Aug;46(4):154-157. doi: 10.1111/jmp.12298.

Abstract

Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection.

Keywords: HIV; RNA; CD4; fat; inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes / metabolism*
  • Chronic Disease
  • India
  • Intra-Abdominal Fat / metabolism
  • Intra-Abdominal Fat / physiopathology
  • Intra-Abdominal Fat / virology
  • Macaca mulatta
  • Male
  • Simian Acquired Immunodeficiency Syndrome / physiopathology*
  • Simian Acquired Immunodeficiency Syndrome / virology
  • Simian Immunodeficiency Virus / physiology
  • Subcutaneous Fat / metabolism
  • Subcutaneous Fat / physiopathology
  • Subcutaneous Fat / virology