Phototoxicity of strained Ru(ii) complexes: is it the metal complex or the dissociating ligand?

Daniel F Azar; Hassib Audi; Stephanie Farhat; Mirvat El-Sibai; Ralph J Abi-Habib; Rony S Khnayzer

doi:10.1039/c7dt02255g

Phototoxicity of strained Ru(ii) complexes: is it the metal complex or the dissociating ligand?

Dalton Trans. 2017 Sep 12;46(35):11529-11532. doi: 10.1039/c7dt02255g.

Authors

Daniel F Azar¹, Hassib Audi, Stephanie Farhat, Mirvat El-Sibai, Ralph J Abi-Habib, Rony S Khnayzer

Affiliation

¹ Department of Natural Sciences, Lebanese American University, Chouran, Beirut 1102-2801, Lebanon. rony.khnayzer@lau.edu.lb.

PMID: 28748239
DOI: 10.1039/c7dt02255g

Abstract

A photochemically dissociating ligand in Ru(bpy)₂(dmphen)Cl₂ [bpy = 2,2'-bipyridine; dmphen = 2,9-dimethyl-1,10-phenanthroline] was found to be more cytotoxic on the ML-2 Acute Myeloid Leukemia cell line than Ru(bpy)₂(H₂O)₂²⁺ and prototypical cisplatin. Our findings illustrate the potential potency of diimine ligands in photoactivatable Ru(ii) complexes.