Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines

Emilie Alirol; Teodora E Wi; Manju Bala; Maria Luiza Bazzo; Xiang-Sheng Chen; Carolyn Deal; Jo-Anne R Dillon; Ranmini Kularatne; Jutta Heim; Rob Hooft van Huijsduijnen; Edward W Hook; Monica M Lahra; David A Lewis; Francis Ndowa; William M Shafer; Liz Tayler; Kimberly Workowski; Magnus Unemo; Manica Balasegaram

doi:10.1371/journal.pmed.1002366

Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines

PLoS Med. 2017 Jul 26;14(7):e1002366. doi: 10.1371/journal.pmed.1002366. eCollection 2017 Jul.

Authors

Emilie Alirol¹, Teodora E Wi², Manju Bala³, Maria Luiza Bazzo⁴, Xiang-Sheng Chen⁵, Carolyn Deal⁶, Jo-Anne R Dillon⁷, Ranmini Kularatne⁸, Jutta Heim¹, Rob Hooft van Huijsduijnen¹, Edward W Hook⁹, Monica M Lahra¹⁰, David A Lewis¹¹, Francis Ndowa¹², William M Shafer¹³, Liz Tayler², Kimberly Workowski¹⁴, Magnus Unemo¹⁵, Manica Balasegaram¹

Affiliations

¹ Global Antibiotics Research and Development Partnership (GARDP), Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
² World Health Organization (WHO), Geneva, Switzerland.
³ Regional STD Teaching, Training & Research Centre, VMMC and Safdarjung Hospital, New Delhi, India.
⁴ Federal University of Santa Catarina, Florianópolis, Brazil.
⁵ National Center for STD Control, Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Dermatology, Nanjing, China.
⁶ STD Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Rockville, Maryland, United States of America.
⁷ University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
⁸ Centre for HIV & Sexually Transmitted Infections, National Institute for Communicable Diseases, Johannesburg, South Africa.
⁹ University of Alabama, Birmingham, Alabama, United States of America.
¹⁰ World Health Organization Collaborating Centre for Sexually Transmitted Diseases, South Eastern Area Laboratory Services, The Prince of Wales Hospital, Sydney, Australia.
¹¹ Western Sydney Sexual Health Centre, Parramatta, NSW, Australia, and Marie Bashir Institute for Infectious Diseases and Biosecurity & Sydney Medical School-Westmead, University of Sydney, Westmead, Australia.
¹² Skin & GU Medicine Clinic, Harare, Zimbabwe.
¹³ Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America, and Laboratories of Bacterial Pathogenesis, VA Medical Center, Decatur, Georgia, United States of America.
¹⁴ Department of Medicine, Division of Infectious Diseases, Emory University, Atlanta, Georgia, United States of America.
¹⁵ World Health Organization Collaborating Centre for Gonorrhoea and other STIs, Örebro University, Örebro, Sweden.

Abstract

Emilie Alirol and colleagues discuss the development of new treatments for gonorrhea.

MeSH terms

Anti-Bacterial Agents / analysis
Anti-Bacterial Agents / pharmacology*
Drug Resistance, Bacterial*
Gonorrhea / drug therapy*
Gonorrhea / microbiology
Neisseria gonorrhoeae / drug effects*
Research / trends

Substances

Anti-Bacterial Agents

Grants and funding

The authors received no specific funding for this work.