MHC Class I Cross-Presentation: Stage Lights on Sec22b

Sebastian Montealegre; Peter van Endert

doi:10.1016/j.it.2017.07.002

MHC Class I Cross-Presentation: Stage Lights on Sec22b

Trends Immunol. 2017 Sep;38(9):618-621. doi: 10.1016/j.it.2017.07.002. Epub 2017 Jul 22.

Authors

Sebastian Montealegre¹, Peter van Endert²

Affiliations

¹ Institut National de la Santé et de la Recherche Médicale, Unité 1151, 75015 Paris, France; Université Paris Descartes, Faculté de Médecine, 75015 Paris, France; Centre National de la Recherche Scientifique, Unité 8253, 75015 Paris, France.
² Institut National de la Santé et de la Recherche Médicale, Unité 1151, 75015 Paris, France; Université Paris Descartes, Faculté de Médecine, 75015 Paris, France; Centre National de la Recherche Scientifique, Unité 8253, 75015 Paris, France. Electronic address: peter.van-endert@inserm.fr.

PMID: 28743621
DOI: 10.1016/j.it.2017.07.002

Abstract

Efficient (cross-)presentation of antigens internalized by dendritic cells (DCs) requires vesicular communication between the early secretory and the endocytic/phagocytic pathways, in which the Sec22b protein has been suggested to have a key role. Here, we undertake a critical assessment of two new studies that evaluate the role of Sec22b using gene-targeted mice and come to contradictory conclusions.

Publication types

Review
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Cross-Priming*
Cytotoxicity, Immunologic
Dendritic Cells / immunology*
Endocytosis
Histocompatibility Antigens Class I / immunology*
Mice
Mice, Knockout
R-SNARE Proteins / genetics
R-SNARE Proteins / immunology*
Secretory Pathway

Substances

Histocompatibility Antigens Class I
R-SNARE Proteins
Sec22b protein, mouse