One-pot synthesis of three-dimensional Mn3O4 microcubes for high-level sensitive detection of head and neck cancer drug nimorazole

Rajaji Umamaheswari; Muthumariappan Akilarasan; Shen-Ming Chen; Yi-Hui Cheng; Veerappan Mani; Sakthivel Kogularasu; Fahad M A Al-Hemaid; M Ajmal Ali; Xiaoheng Liu

doi:10.1016/j.jcis.2017.07.006

One-pot synthesis of three-dimensional Mn₃O₄ microcubes for high-level sensitive detection of head and neck cancer drug nimorazole

J Colloid Interface Sci. 2017 Nov 1:505:1193-1201. doi: 10.1016/j.jcis.2017.07.006. Epub 2017 Jul 4.

Authors

Rajaji Umamaheswari¹, Muthumariappan Akilarasan¹, Shen-Ming Chen², Yi-Hui Cheng¹, Veerappan Mani³, Sakthivel Kogularasu¹, Fahad M A Al-Hemaid⁴, M Ajmal Ali⁴, Xiaoheng Liu⁵

Affiliations

¹ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
² Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: smchen78@ms15.hinet.net.
³ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC; Graduate Institute of Biomedical and Biochemical Engineering, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
⁴ Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
⁵ Key Laboratory of Education Ministry for Soft Chemistry and Functional Materials, Nanjing University of Science and Technology, Nanjing 210094, China. Electronic address: xhliu@mail.njust.edu.cn.

PMID: 28738516
DOI: 10.1016/j.jcis.2017.07.006

Abstract

We described a three-dimensional Mn₃O₄ microcubes (3D-Mn₃O₄MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D-Mn₃O₄ MCs possess large active area and high conductivity, and 3D-Mn₃O₄ MCs film modified screen-printed carbon electrode (3D-Mn₃O₄MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025-8060µM concentration range and the detection limit was 6nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations.

Keywords: Anti-cancer drug; Biosensor; Drug analysis; Electrochemical biosensor; Modified electrode; Nimorazole; Transition metal oxides.

MeSH terms

Antitrichomonal Agents / blood
Biosensing Techniques / methods*
Carbon / chemistry
Electrochemical Techniques / methods*
Electrodes*
Head and Neck Neoplasms*
Humans
Manganese Compounds / chemistry*
Nimorazole / blood*
Oxides / chemistry*
Tablets / metabolism*

Substances

Antitrichomonal Agents
Manganese Compounds
Oxides
Tablets
Nimorazole
manganese oxide
Carbon