Short-term reconsultation, hospitalisation, and death rates after discharge from the emergency department in patients with acute heart failure and analysis of the associated factors. The ALTUR-ICA Study

Med Clin (Barc). 2018 Mar 9;150(5):167-177. doi: 10.1016/j.medcli.2017.06.004. Epub 2017 Jul 21.
[Article in English, Spanish]

Abstract

Background and objectives: The aim of this study was to define the following in patients with acute heart failure (AHF) discharged directly from accident and emergency (A&E): rates of reconsultation to A&E and hospitalisation for AHF, and all-cause death at 30 days, rate of combined event at 7 days and the factors associated with these rates.

Patients and method: The study included patients consecutively diagnosed with AHF during 2 months in 27 Spanish A&E departments who were discharged from A&E without hospitalisation. We collected 43 independent variables, monitored patients for 30 days and evaluated predictive factors for adverse events using Cox regression analysis.

Results: We evaluated 785 patients (78±9) years, 54.7% women). The rates of reconsultation, hospitalisation, and death at 30 days and the combined event at 7 days were: 26.1, 15.7, 1.7 and 10.6%, respectively. The independent factors associated with reconsultation were no endovenous diuretics administered in A&E (HR 2.86; 95% CI 2.01-4.04), glomerular filtration rate (GFR)<60ml/min/m2 (1.94; 1.37-2.76) and previous AHF episodes (1.48; 1.02-2.13); for hospitalisation these factors were no endovenous diuretics in A&E (2.97; 1.96-4.48), having heart valve disease (1.61; 1.04-2.48), blood oxygen saturation at arrival to A&E<95% (1.60; 1.06-2.42); and for the combined event no endovenous diuretics in A&E (3.65; 2.19-6.10), GFR<60ml/min/m2 (2.22; 1.31-3.25), previous AHF episodes (1.95; 1.04-3.25), and use of endovenous nitrates (0.13; 0.02-0.99).

Conclusion: This is the first study in Spain to describe the rates of adverse events in patients with AHF discharged directly from A&E and define the associated factors. These data should help establish the most adequate approaches to managing these patients.

Keywords: Accident and emergency; Acute heart failure; Death; Hospitalisation; Hospitalización; Insuficiencia cardiaca aguda; Mortalidad; Reconsulta; Reconsultation; Urgencias.

Publication types

  • Multicenter Study

MeSH terms

  • Acute Disease
  • Aged
  • Cause of Death
  • Disease Management
  • Diuretics / therapeutic use
  • Emergency Service, Hospital*
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Heart Failure / epidemiology*
  • Heart Failure / mortality
  • Heart Failure / therapy
  • Hospital Mortality
  • Humans
  • Hypoxia / epidemiology
  • Male
  • Patient Readmission / statistics & numerical data*
  • Proportional Hazards Models
  • Referral and Consultation / statistics & numerical data*
  • Risk Factors
  • Spain / epidemiology

Substances

  • Diuretics