Myocardial viability-State of the art: Is it still relevant and how to best assess it with imaging?

Trends Cardiovasc Med. 2018 Jan;28(1):24-37. doi: 10.1016/j.tcm.2017.07.001. Epub 2017 Jul 10.

Abstract

Despite major advances, ischemic cardiomyopathy (ICM) remains a significant cause of death and disability worldwide, with coronary artery disease (CAD) the leading cause of left ventricular (LV) systolic dysfunction. Coronary revascularization may improve LV function, heart failure symptoms and cardiovascular outcomes in high-risk patients with myocardial viability. Multiple imaging modalities have been utilized to detect viable myocardium and predict functional recovery following revascularization. Dobutamine stress echocardiography (DSE), nuclear imaging and cardiac MRI (CMR) are frequently used to assess viability. This review will summarize the extant literature on this topic, describe the role and methods for viability imaging in modern clinical practice, provide a patient-centered perspective regarding the controversies surrounding the current utility of viability imaging, as well as discuss future directions.

Keywords: coronary artery disease; myocardial viability; noninvasive imaging.

Publication types

  • Review

MeSH terms

  • Cardiac Imaging Techniques*
  • Echocardiography
  • Humans
  • Magnetic Resonance Imaging
  • Multidetector Computed Tomography
  • Myocardial Ischemia / diagnostic imaging*
  • Myocardial Ischemia / pathology
  • Myocardial Ischemia / physiopathology
  • Myocardium / pathology*
  • Positron-Emission Tomography
  • Predictive Value of Tests
  • Prognosis
  • Tissue Survival
  • Tomography, Emission-Computed, Single-Photon