Evolutionary dynamics of recent peste des petits ruminants virus epidemic in China during 2013-2014

Virology. 2017 Oct:510:156-164. doi: 10.1016/j.virol.2017.07.018. Epub 2017 Jul 19.

Abstract

Peste des petits ruminants virus (PPRV) causes a highly contagious disease, peste des petits ruminants (PPR), in sheep and goats which has been considered as a serious threat to the local economy in Africa and Asia. However, the in-depth evolutionary dynamics of PPRV during an epidemic is not well understood. We conducted phylogenetic analysis on genomic sequences of 25 PPRV strains from China 2013-2014 outbreaks. All these strains clustered into a novel clade in lineage 4. An evolutionary rate of 2.61 × 10-6 nucleotide substitutions per site per day was estimated, dating the most recent common ancestor of PPRV China 2013-2014 strains to early August 2013. Transmission network analysis revealed that all the virus sequences could be grouped into five clusters of infection, suggesting long-distance animal transmission play an important role in the spread of PPRV in China. These results expanded our knowledge for PPRV evolution to achieve effective control measures.

Keywords: Evolution; Peste des petits ruminants virus; Phylogenetic analysis; Transmission.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • China / epidemiology
  • Cluster Analysis
  • Epidemics*
  • Evolution, Molecular*
  • Genetic Variation*
  • Genome, Viral
  • Goats
  • Molecular Epidemiology
  • Mutation Rate
  • Peste-des-Petits-Ruminants / epidemiology*
  • Peste-des-Petits-Ruminants / virology*
  • Peste-des-petits-ruminants virus / classification*
  • Peste-des-petits-ruminants virus / genetics*
  • Peste-des-petits-ruminants virus / isolation & purification
  • Phylogeny
  • Sequence Analysis, DNA
  • Sheep