Selective Therapeutic Intervention: A Challenge against Off-Target Effects

Filip Rázga; Veronika Némethová

doi:10.1016/j.molmed.2017.06.007

Selective Therapeutic Intervention: A Challenge against Off-Target Effects

Trends Mol Med. 2017 Aug;23(8):671-674. doi: 10.1016/j.molmed.2017.06.007. Epub 2017 Jul 18.

Authors

Filip Rázga¹, Veronika Némethová²

Affiliations

¹ Department for Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Dúbravská cesta 9, 845 41 Bratislava, Slovak Republic. Electronic address: filip.razga@savba.sk.
² Department for Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Dúbravská cesta 9, 845 41 Bratislava, Slovak Republic.

PMID: 28732687
DOI: 10.1016/j.molmed.2017.06.007

Abstract

Despite the massive global spend on biology-driven drug discovery, tackling the issue of side effects and adverse events resulting from drug promiscuity represents a persistent challenge. Although delivering authentic medical innovations today is more complex than ever, minimization of off-target effects should be a priority.

Keywords: drug design; off-targets; selective intervention; side effects; target recognition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Drug Design*
Humans