Spontaneous pregnancy during ulipristal acetate treatment of giant uterine leiomyoma

J Clin Pharm Ther. 2018 Feb;43(1):121-123. doi: 10.1111/jcpt.12590. Epub 2017 Jul 21.

Abstract

What is known and objective: Ulipristal acetate, a progesterone receptor modulator, pharmacologically inhibits endometrial proliferation and thereby prevents pregnancy. It is primarily used as emergency contraception, but also for the treatment of fibroids in women of reproductive age. There have been no published cases of pregnancy, while on therapy with ulipristal acetate.

Case description: In this article, we present a case report of spontaneous pregnancy during ulipristal acetate therapy.

What is new and conclusion: To our knowledge, this is the first patient with spontaneous conception, while on ulipristal acetate treatment. There were no drug-related complications, and the pregnancy resulted in the delivery of a healthy baby.

Keywords: contraceptive agents; leiomyoma; pregnancy outcome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Contraception, Postcoital / methods
  • Female
  • Humans
  • Leiomyoma / drug therapy*
  • Leiomyoma / metabolism
  • Norpregnadienes / therapeutic use*
  • Pregnancy
  • Receptors, Progesterone / metabolism

Substances

  • Norpregnadienes
  • Receptors, Progesterone
  • ulipristal acetate