The Ebola virus (EBOV) outbreak in West Africa during 2013-2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care. This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models. Furthermore, the data support that, in nonhuman primates, the Makona strain of EBOV may be less virulent than the Kikwit strain of EBOV. The applicability of these findings as potential diagnostic and management tools for EVD in humans warrants further investigation.
Keywords: EBOV; EVD; Ebola virus; Ebola virus disease; Kikwit strain; Macaca fascicularis; Macaca mulatta; Makona strain; Maryland; USA; cynomolgus macaques; early indicators of infection; monkeys; nonhuman primate models; rhesus macaques; survival; viruses; zoonoses.