Synthesis of Cyclic Peptide Mimetics by the Successive Ring Expansion of Lactams

Abstract

A successive ring-expansion protocol is reported that enables the controlled insertion of natural and non-natural amino acid fragments into lactams. Amino acids can be installed into macrocycles via an operationally simple and scalable iterative procedure, without the need for high dilution. This method is expected to be of broad utility, especially for the synthesis of medicinally important cyclic peptide mimetics.

Keywords: cyclic peptides; lactams; macrocycles; medium-sized rings; ring expansion.